Poly (I:C)

Poly (I:C)

TLR3 is a member of the toll-like-receptor (TLR) family recognizing pathogen-associated molecular patterns.
1
TLR3 recognizes (virally derived) double- or single-stranded RNA leading to activation of immune cells. The natural ligands for TLR3 can be mimicked by synthetic RNAs (oligoribonucleotides; ORNs) like polyinosinic-polycytidylic acid (poly (I:C)), which hybridizes to form RNA double strands in aqueous solutions with ionic strength.

Background information

Poly (I:C) can activate the nuclear transcription factor NF-κB1 as well as stimulate the production of type I interferons (IFNs) leading to cytokine secretion
2,3
. Poly (I:C) is one of the most potent agonists for the maturation of myeloid dendritic cells (mDCs)
4
. Additionally, maturation markers like CD80 are activated upon treatment of dendritic cells (DCs) with poly (I:C).

Applications

Poly (I:C) can be used for the activation of immune cells, such as
  1. Dendritic cells (DCs).
  2. Antiviral activity.
Product options: 2

Product information

Size
Order no.
Price

Poly (I:C)

  • For research use only
50 mg
130-112-563
EUR 237,00 

Poly (I:C)

  • For research use only
5×50 mg
130-112-562
EUR 618,00