StemMACS™ DAPT

StemMACS™ DAPT

StemMACS™ DAPT is a small molecule inhibitor of gamma-secretase that prevents Notch signaling.

Background information

StemMACS™ DAPT is a cell-permeable dipeptide that inhibits the protease γ-secretase, a key component of the Notch signaling pathway. The Notch pathway is involved in various developmental cell fate and lineage decisions, making the small molecule inhibitor DAPT a valuable tool for the modulation of stem cell differentiation in cell culture. In addition, γ-secretase plays a role in processing of amyloid precursor protein (APP) to β-amyloid, a component of the senile plaques characteristic for Alzheimer’s disease. Inhibition of γ-secretase by DAPT has been shown to cause a dose-dependent reduction of β-amyloid levels in primary neuronal cultures as well as
in vivo
.

Applications

Published applications for DAPT include:
  • Differentiation of human PSCs into retinal pigment epithelium (RPE) cells1
  • Neural differentiation of human PSCs2
  • Pancreatic differentiation of human PSCs3
  • Nociceptor differentiation from human PSCs4
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Product information

Size
Order no.
Price

StemMACS DAPT

  • For research use only
5 mg
130-110-489
EUR 161,00