Mouse Flt3-Ligand

Mouse Flt3-Ligand

Flt3-Ligand stands for Fms-related tyrosine kinase 3 ligand. Mouse Flt3-Ligand is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse Flt3-Ligand can be used for a variety of applications, including:
  • Inducing of maturation and expansion of dendritic cells (DCs) in vivo and for the in vitro generation of bone marrow-derived DCs.
  • Generation of eosinophils from bone marrow progenitor cells.
  • Studies on allergic airway inflammation in mouse models.

Background information

Fms-related tyrosine kinase 3 ligand (Flt3-ligand) is a growth factor that regulates early hematopoiesis. Flt3-ligand belongs to a small family of α-helical cytokines. In synergy with other growth factors like G-CSF, GM-CSF, SCF, and IL-3 Flt3-ligand stimulates the proliferation and differentiation of primitive hematopoietic stem cells. Early B cell lineage differentiation as well as expansion of monocytes and immature dendritic cells is stimulated. Flt3-ligand is expressed by T lymphocytes and bone marrow stromal fibroblasts as a membrane-bound and a soluble isoform. Both isoforms signal through the tyrosine kinase receptor Flt3/Flk-2, which is restricted to cells of hematopoietic origin. Mouse Flt3-Ligand is also active on human cells.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Proliferation of mouse AML5 cells
  • research grade: ≥ 5×
    10
    5
    U/mg
Product options: 2

Product information

Size
Order no.
Price

Mouse Flt3-Ligand, research grade

  • E. coli
  • For research use only
10 µg
130-094-038
EUR 190,00 

Mouse Flt3-Ligand, research grade

  • E. coli
  • For research use only
100 µg
130-097-372
EUR 630,00 

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