Human GRO-α

Human GRO-α

GRO-α stands for growth regulated oncogene α. Human GRO-α is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human GRO-α can be used for a variety of applications, including:
  • Study of granulocyte chemotaxis.
  • Investigation of angiogenesis process and tumor growth.

Alternative Names

CXCL1, MGSAα

Background information

GRO-α also known as chemokine (C-X-C motif) ligand 1 (CXCL1), and melanoma growth-stimulating activity alpha (MSGA-α), belongs to the CXC chemokine family and acts as neutrophil and basophils chemoattractant. GRO-α is secreted by epithelial cells and myeloid cells, such as macrophages and neutrophils and can be induced by inflammatory mediators as IL-1 and TNF. It signals via the chemokine receptor CXCR2 and induces chemotaxis of granulocytes during process of inflammation, angiogenesis, and tumorigenesis. GRO-α is also secreted by melanoma cells and is involved in pathogenesis of tumors and inflammatory disorders of the neural system.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Mobilization of intracellular calcium of human neutrophils
Product options: 3

Product information

Size
Order no.
Price

Human GRO-α, research grade

  • E. coli
  • For research use only
5 µg
130-094-620
EUR 55,00 

Human GRO-α, research grade

  • E. coli
  • For research use only
25 µg
130-093-869
EUR 190,00 

Human GRO-α, research grade

  • E. coli
  • For research use only
100 µg
130-108-974
EUR 515,00