Human FGF-7

Human FGF-7

FGF-7 stands for fibroblast growth factor 7. Human FGF-7 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human FGF-7 can be used for a variety of applications including:
  • Induction of proliferation and differentiation of epithelial cells.
  • Stimulation of proliferation of keratinocytes.
  • ES/iPS cell culture.

Alternative Names

KGF, HBGF-7

Background information

Fibroblast growth factor 7 (FGF-7), also termed keratinocyte growth factor (KGF), is a member of the FGF family. FGFs are involved in embryonic development, angiogenesis, wound healing, and tumorigenesis. FGF-7 acts specifically on various types of epithelial cells including keratinocytes of the skin, intestinal epithelial cells, and hepatocytes. It is involved in the repair of injured skin and mucosal tissues by stimulating the proliferation, migration, and differentiation of epithelial cells. Furthermore, FGF-7 can protect epithelial cells from damaging effects. FGF-7 shows high structural homology and similar biological characteristics with FGF-10. Both factors are predominantly synthesized by mesenchymal cells. Human FGF-7 shows species cross-reactivity and is active among others on mouse cells.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.
Premium-grade
cytokines offer the convenience of high and well-defined biological activities and allow exact unit dosing for demanding applications. The biological activity is determined after lyophilization and reconstitution, and normalized to WHO/NIBSC standards whenever available. In general, endotoxin levels are <0.01 ng/μg (<0.1 EU/μg), and purities are >97%. Lot-specific certificates of analysis are available on request (macstec@miltenyibiotec.de).

Biological activity

  • Proliferation of 4MBr-5 cells (NIBSC 03/150)
  • premium grade: ≥ 2×
    10
    5
    U/mg
  • research grade: ≥ 1×
    10
    5
    U/mg
Product options: 5

Product information

Size
Order no.
Price

Human FGF-7, research grade

  • E. coli
  • For research use only
10 µg
130-093-849
EUR 155,00 

Human FGF-7, research grade

  • E. coli
  • For research use only
25 µg
130-097-175
EUR 290,00 

Human FGF-7, premium grade

  • E. coli
  • For research use only
10 µg
130-097-173
EUR 190,00 

Human FGF-7, premium grade

  • E. coli
  • For research use only
25 µg
130-097-178
EUR 365,00 

Human FGF-7, premium grade

  • E. coli
  • For research use only
100 µg
130-097-176
EUR 840,00