Human CD137 (4-1BB)-Ligand

Human CD137 (4-1BB)-Ligand

Human CD137 (4-1BB)-Ligand is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human CD137 (4-1BB)-Ligand can be used for a variety of applications including:
  • In vitro costimulation of T cells for optimal activation, expansion, or memory formation.
  • Investigation of CD137/CD137-Ligand intracellular signaling.

Alternative Names

4-1BB ligand, TNFRSF9-Ligand

Background information

CD137-Ligand, also known as 4-1BB-Ligand or TNFRSF9-Ligand, is the natural agonist of the CD137 receptor, and a member of the TNF superfamily. CD137-Ligand is expressed on antigen presenting cells, such as dendritic cells, B cells, and macrophages. The binding of CD137-Ligand to its receptor plays a central role in co-stimulation of T cells by antigen presenting cells, and it is required for development of memory T cells. CD137-Ligand is studied for its role in the activation of immune response against infections and cancer, and for its involvement in autoimmunity. CD137-Ligand exists as a membrane-bound and a soluble form resulting from proteolytic cleavage of the extracellular domain. Like other Ligands from the TNFSF family, active CD137-Ligand is expected to form a non-covalent homotrimer.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Secretion of IL-8 by human PBMCs
  • research grade: ≥ 1×
    10
    5
    U/mg
Product options: 2

Product information

Size
Order no.
Price

Human CD137 (4-1BB)-Ligand, research grade

  • E. coli
  • For research use only
5 µg
130-105-768
EUR 55,00 

Human CD137 (4-1BB)-Ligand, research grade

  • E. coli
  • For research use only
20 µg
130-105-767
EUR 190,00