Human BAFF

Human BAFF

BAFF stands for B cell activating factor, also termed BLys. Human BAFF is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human BAFF can be used for a variety of applications, including:
  • Study of B cell differentiation and activation.
  • Investigation of TNF-receptor superfamily signaling.

Alternative Names

TNFSF13B, BLys

Background information

B cell activating factor (BAFF) is a ligand belonging to the TNF superfamily and plays an important role in regulation of lymphocytes, especially peripheral B cells. It is expressed in T cells, dendritic cells, macrophages, and monocytes and binds three receptors, TACI, BCMA, and the BAFF specific receptor (BAFF-R), which is essential for the B cell promoting activity. BAFF induces stimulation of B and T cell function, and promotes maturation and survival of B cell lineage cells and peripheral B cells. High expression of BAFF increases Tʜ1 response, and correlates with B cell malignancies and autoimmunity, such as systemic lupus erythematosus and rheumatoid arthritis, allograft reactions, and celiac disease. On the contrary, inefficient production of BAFF can lead to an impair of B cell activation and immunodeficiency. Recombinant human BAFF contains the TNF-like portion of the extracellular domain, which shares 72% amino acid sequence identity with mouse BAFF.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Mouse splenocyte survival assay
  • research grade: ≥ 2×
    10
    3
    U/mg
Product options: 3

Product information

Size
Order no.
Price

Human BAFF, research grade

  • E. coli
  • For research use only
5 µg
130-093-806
EUR 55,00 

Human BAFF, research grade

  • E. coli
  • For research use only
20 µg
130-093-807
EUR 190,00 

Human BAFF, research grade

  • E. coli
  • For research use only
100 µg
130-108-987
EUR 620,00