Clone:
REA416
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
Ltbr, Tnfcr, LTbetaR, Ltar, CD18, LTBR, Tnfrsf3

Specifications for LT-βR Antibody, anti-mouse, REAfinity™

Overview

Clone REA416 recognizes the mouse lymphotoxin β receptor (LT-βR) antigen, a 61 kD single-pass type I membrane protein which is also known as tumor necrosis factor receptor superfamily member 3 (Tnfrsf3). LT-βR is a member of the TNF receptor family that play a role in the development and organization of lymphoid tissues. Membrane-bound lymphotoxin LTα1LTβ2 and LIGHT (TNFSF14) are members of the TNF family of cytokines. Both are primarily expressed on lymphocytes and each can deliver signals through LT-βR. In contrast, LT-βR is primarily expressed on epithelial, stromal and myeloid cells, but not lymphocytes, suggesting that it may participate in the communication between lymphocytes and surrounding epithelial and stromal cells.
Additional information: Clone REA416 displays negligible binding to Fc receptors.

Alternative names

Ltbr, Tnfcr, LTbetaR, Ltar, CD18, LTBR, Tnfrsf3

Detailed product information

Technical specifications

CloneREA416
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenLT-βR
Alternative names of antigenLtbr, Tnfcr, LTbetaR, Ltar, CD18, LTBR, Tnfrsf3
Molecular mass of antigen [kDa]42
Distribution of antigenepithelial cells, stromal cells
Entrez Gene ID17000
RRIDAB_2652668, AB_2652669, AB_2652670, AB_2652671, AB_2652672, AB_2652667

Resources for LT-βR Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for LT-βR Antibody, anti-mouse, REAfinity™

Publications

  1. Force, W. R. et al. (1995) Mouse lymphotoxin-beta receptor. Molecular genetics, ligand binding, and expression. J. Immunol. 155(11): 5280-5288
  2. Lkhagvasuren, E. et al. (2013) Lymphotoxin β receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells. J. Immunol. 190(10): 5110-5117
  3. Onder, L. et al. (2013) Endothelial cell-specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation. J. Exp. Med. 210(3): 465-473

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