Clone:
REAL788
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
IFN-gamma, IFNg, IFN gamma, Interferon gamma

Specifications for IFN-γ Antibody, anti-human, REAdye_lease™

Overview

Clone REAL788 is an antibody fragment derived from the full IFN-γ antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL788 recognizes the human IFN-γ antigen, a pleiotropic cytokine of the type II class of interferons. Interferon gamma (IFN-γ) is produced by lymphocytes, primarily activated T lymphocytes, that are involved in inflammatory immune responses. It functions as a potent activator of macrophages, increases the antiviral and antitumor effects of the type I interferons and has antiproliferative effects on transformed cells. IFN-γ is predominantly released by memory and effector CD4
+
and CD8
+
T cells as well as by NK cells upon activation.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

IFN-gamma, IFNg, IFN gamma, Interferon gamma

Detailed product information

Technical specifications

CloneREAL788
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenIFN-γ
Alternative names of antigenIFN-gamma, IFNg, IFN gamma, Interferon gamma
Distribution of antigenmacrophages, T cells, NK cells, CD4+ T cells, CD8+ T cells

References for IFN-γ Antibody, anti-human, REAdye_lease™

Publications

  1. Green, J. A. et al. (1969) Immune specific induction of interferon production in cultures of human blood lymphocytes. Science 164(3886): 1415-1417
  2. Gray, P. W. et al. (1982) Structure of the human immune interferon gene. Nature 298(5877): 859-863
  3. Schoenborn, J. R. et al. (2007) Regulation of interferon-gamma during innate and adaptive immune responses. Adv. Immunol. 96: 41-101
  4. Smith, B.C. et al. (2020) The impact of regional astrocyte interferon-γ signaling during chronic autoimmunity: a novel role for the immunoproteasome. J Neuroinflammation 17(1): 184