TSLP stands for thymic stromal lymphopoietin. Human TSLP is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Specifications for Human TSLP

Overview

TSLP stands for thymic stromal lymphopoietin. Human TSLP is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human TSLP can be used for a variety of applications including:
  • Activation of immature DCs.
  • Expansion, differentiation, and activation of B cells.
  • Support in T cell growth and survival.
  • Studies on initiation of allergic diseases.

Detailed product information

Background information

TSLP is a hematopoietic cytokine that plays a critical role as regulator of T helper (T
H
)2 driven inflammation. It is highly expressed in skin keratinocytes and airway epithelial cells as well as in gut and thymus. TSLP is an interleukin 7 (IL-7)-like cytokine that binds to a heterodimeric receptor complex consisting of the alpha chain of the IL-7 receptor (IL-7Rα) and the TSLP receptor chain (TSLPR). It is able to promote the activation of B cells and dendritic cells (DCs). TSLP activated DCs polarize naive CD4
+
T cells to differentiate into inflammatory T
H
2 cells that produce the pro-allergic cytokines IL-4, IL-5, IL-13, and TNF-α. Furthermore TSLP supports B cell expansion and differentiation. It induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c
+
DCs. Like IL-7, TSLP has been shown to activate and phosphorylate the transcription factors STAT3 and STAT5.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Resources for Human TSLP

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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