Type of antibody:
Primary antibodies
mouse IgG1κ
Alternative names:
QA1, EA1.2, EA2.1, HLA-6.2, MHC, HLA-E

Extended validation for HLA-E Antibody, anti-human


Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with 3D12
SN3 A5-2H10+
Cells were incubated with an excess of purified unconjugated HLA-E (3D12) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for HLA-E Antibody, anti-human


The 3D12 monoclonal antibody recognizes the human HLA-E protein, a member of the human leukocyte antigen family. HLA-E is a non-classical MHC molecule (MHC-Ib) with limited polymorphisms, which is expressed on the cell surface in a heterodimeric complex with β2-microglobulin. HLA-E is ubiquitously expressed and has a specialized role in NK cell recognition. It binds a restricted set of peptides, e.g., derived from other class I leader sequences. The complex is recognized by NKG2A on NK cells. This recognition protects the HLA-E–expressing cell from NK cell killing. Recently HLA-E recognition by a specialised subset of CD8 T cells has been implicated in pathogen recognition as well as autoimmunity.

Alternative names

QA1, EA1.2, EA2.1, HLA-6.2, MHC, HLA-E

Detailed product information

Technical specifications

Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Type of antibodyPrimary antibodies
Alternative names of antigenQA1, EA1.2, EA2.1, HLA-6.2, MHC, HLA-E
Molecular mass of antigen [kDa]38
Entrez Gene ID3133
RRIDAB_2751537, AB_2752020, AB_2751990, AB_2652189, AB_2751547

Resources for HLA-E Antibody, anti-human


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References for HLA-E Antibody, anti-human


  1. Pietra, G. et al. (2010)
    The emerging role of HLA-E-restricted CD8
    T lymphocytes in the adaptive immune response to pathogens and tumors.
    J. Biomed. Biotechnol. : 907092
  2. Lu, L. et al. (2008)
    Generation and regulation of CD8
    regulatory T cells.
    Cell. Mol. Immunol. 5(6): 401-406
  3. Jiang, H. et al. (2010)
    HLA-E-restricted regulatory CD8
    T cells are involved in development and control of human autoimmune type 1 diabetes.
    J. Clin. Invest. 120(10): 3641-3650

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