Clone:
REAL1173
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
GCG, Pro-glucagon, Glucagon-like peptide, GLP-1, GLP-2, Glicentin, GRPP, OXM, OXY

Specifications for Glucagon Antibody, anti-human, REAdye_lease™

Overview

Clone REAL1173 is an antibody fragment derived from the full Glucagon antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1173 recognizes human Glucagon, also known as GCG, which is predominantly secreted from the alpha cells of the pancreas. Glucogon is cleaved into 8 chains and plays a key role in glucose metabolism and homeostasis. Glucagon is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. It raises plasma glucose levels in response to insulin-induced hypoglycemia and therfore is important in initiating and maintaining hyperglycemic conditions in diabetes. Used to treat severe hypoglycemia in insulin-dependent diabetics.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

GCG, Pro-glucagon, Glucagon-like peptide, GLP-1, GLP-2, Glicentin, GRPP, OXM, OXY

Detailed product information

Technical specifications

CloneREAL1173
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenGlucagon
Alternative names of antigenGCG, Pro-glucagon, Glucagon-like peptide, GLP-1, GLP-2, Glicentin, GRPP, OXM, OXY
Distribution of antigenLangerhans cells, neurons, brain, pancreas

Resources for Glucagon Antibody, anti-human, REAdye_lease™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for Glucagon Antibody, anti-human, REAdye_lease™

Publications

  1. Kulina, G. R. et al. (2016) THE ROLE OF GLUCAGON IN THE PATHOPHYSIOLOGY AND MANAGEMENT OF DIABETES. Endocr Pract. 22(5): 612-621
  2. Chabenne, J. R. et al. (2020) Structural Refinement of Glucagon for Therapeutic Use. J. Med. Chem. 663(7): 3447-3460
  3. Janah, L. et al. (2019) Glucagon Receptor Signaling and Glucagon Resistance. Int J Mol Sci 20(13): 3314

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