Clone:
REA533
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
HbF, α2γ2

Specifications for Fetal Hemoglobin Antibody, anti-human, REAfinity™

Overview

Clone REA533 recognizes the human fetal hemoglobin (HbF) antigen, a form of hemoglobin present during fetal development. The hemoglobin molecule is a tetramer composed of two subunits of α-like globin peptide chains and two subunits of the β-like globin peptides, along with heme moieties necessary for this molecule´s oxygen-carrying capacity. When production of the first enucleated definitive erythrocytes commences from stem and progenitor cells in the fetal liver, the predominant β-like globin molecule produced is γ-globin. The γ-globin chains combine with adult α-globin chains into a stable tetramer forming HbF. Shortly after the time of birth there is a switch from predominant expression of HbF to adult hemoglobin (HbA), which is mediated by a transcriptional switch in definitive erythroid progenitors from γ- to β-globin. The synthesis of HbF is normally reduced to very low levels of less than 0.6% of the total hemoglobin in adults. HbF levels may be increased in adults in a number of inherited and acquired disorders. The clinical significance of these conditions with raised HbF relates to their interaction in disorders such as sickle cell disease and β-thalassemia in which raised levels of HbF can lead to considerable amelioration of disease severity.
Additional information: Clone REA533 displays negligible binding to Fc receptors.

Alternative names

HbF, α2γ2

Detailed product information

Technical specifications

CloneREA533
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenFetal Hemoglobin
Alternative names of antigenHbF, α2γ2
Molecular mass of antigen [kDa]194(sum of molecular weights of subunits)
Distribution of antigenred blood cells
Entrez Gene ID3039, 3040, 3047, 3048
RRIDAB_2651730, AB_2651731

Resources for Fetal Hemoglobin Antibody, anti-human, REAfinity™

Certificates

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References for Fetal Hemoglobin Antibody, anti-human, REAfinity™

Publications

  1. Akinsheye, I. et al. (2011) Fetal hemoglobin in sickle cell anemia. Blood 118(1): 19-27
  2. Rochette, J. et al. (1994) Fetal hemoglobin levels in adults. Blood 8(4): 213-224
  3. Sankaran, V. G. et al. (2008) Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science 322(5909): 1839-1842

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