Magnetic resonance imaging (MRI) is the most frequently used technique for serial
in vivo
cell tracking applications due to high resolution of soft tissues, which makes it especially useful for imaging of the brain, muscles, or the heart.¹ In order to improve detectability of transplanted cells and produce a strong contrast against surrounding tissue, intracellular labeling of cells with iron oxide particles before transplantation has been described.² FeraTrack Direct Contrast Particles are SPIO nanoparticles specifically formulated for direct uptake from cell culture medium without the need of

Specifications for FeraTrack Direct MRI contrast agents

Overview

Magnetic resonance imaging (MRI) is the most frequently used technique for serial
in vivo
cell tracking applications due to high resolution of soft tissues, which makes it especially useful for imaging of the brain, muscles, or the heart.¹ In order to improve detectability of transplanted cells and produce a strong contrast against surrounding tissue, intracellular labeling of cells with iron oxide particles before transplantation has been described.² FeraTrack Direct Contrast Particles are SPIO nanoparticles specifically formulated for direct uptake from cell culture medium without the need of transfection reagent. Uptake of FeraTrack Direct Contrast Particles was proven by Prussian Blue staining, MRI, and electron microscopy. Biocompatibility was assured by cell expansion and differentiation assays of intracellularly labeled cells. Once within cells, SPIOs can induce decreased signal intensity on T1, T2, and T2*-weighted images.³

Detailed product information

Applications

FeraTrack Direct Contrast Particles are optimized for
in vitro
labeling of cell lines (e.g. NIH-3T3, Jurkat), primary cells (e.g. T cells), and stem cells (e.g. mesenchymal stem cells) independent of an additional transfection reagent.

References for FeraTrack Direct MRI contrast agents

Publications

  1. Rogers, W.J. et al. (2006)
    Technology insight:
    in vivo
    cell tracking by use of MRI.
    Nat. Clin. Pract. Cardiovasc. Med. 10: 554-562
  2. Bulte, J.W. and Kraitchman, D.L. (2004) Iron oxide MR contrast agents for molecular and cellular imaging. NMR Biomed 17: 484-499
  3. Hoehn, M. et al. (2007) Cell tracking using magnetic resonance imaging. J. Physiol. 584: 25-30

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