Clone:
REAL1125
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
Protein disulfide-isomerase A4, ER protein 70, Endoplasmic reticulum resident protein 70, ERp70, ER protein 72, Endoplasmic reticulum resident protein 72, ERp72

Specifications for ERp72 (PDIA4) Antibody, anti-human, REAdye_lease™

Overview

Clone REAL1125 is an antibody fragment derived from the full ERp72 (PDIA4) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL947 recognizes the human ERp72 (PDIA4), a luminal endoplasmic reticulum protein, that belongs to the family of CGHC-containing proteins. ERp72 (PDIA4) is an enzyme, that catalyzes protein folding and thiol-disulfide interchange reactions. It is also known as ERP70 and is described as Protein disulfide isomerase family A member 4. Cytoplasmic expression of ERp72 is found in all tissues, in most glandular epithelia ERp72 is expressed in high levels. ERp72 has a low cancer specificity and is detected in all cancers.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Protein disulfide-isomerase A4, ER protein 70, Endoplasmic reticulum resident protein 70, ERp70, ER protein 72, Endoplasmic reticulum resident protein 72, ERp72

Detailed product information

Technical specifications

CloneREAL1125
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenERp72 (PDIA4)
Alternative names of antigenProtein disulfide-isomerase A4, ER protein 70, Endoplasmic reticulum resident protein 70, ERp70, ER protein 72, Endoplasmic reticulum resident protein 72, ERp72
Distribution of antigentumor cells, endothelial cells, ubiquitous

Resources for ERp72 (PDIA4) Antibody, anti-human, REAdye_lease™

Certificates

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References for ERp72 (PDIA4) Antibody, anti-human, REAdye_lease™

Publications

  1. Mazzarella, R. A. et al. (1990) ERp72, an abundant luminal endoplasmic reticulum protein, contains three copies of the active site sequences of protein disulfide isomerase. J. Biol. Chem. 265(2): 1094-1101
  2. Pawar, H. et al. (2011) Quantitative tissue proteomics of esophageal squamous cell carcinoma for novel biomarker discovery. Cancer Biol. Ther. 12(6): 510-522
  3. Wang, Z. et al. (2020) PDIA4: The basic characteristics, functions and its potential connection with cancer. Biomed Pharmacother . 122: 109688

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