Clone:
REAL1136
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
CCNE, G1/S-specific cyclin-E1, CCNE1

Specifications for Cyclin E1 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL1136 is an antibody fragment derived from the full Cyclin E1 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1136 recognizes the Cyclin E1, also known as CCNE1, that is a member of the highly conserved cyclin family. Cyclins are regulators of CDKs (Cyclin-dependent kinases). In a protein complex it functions as a regulatory subunit of CDK2, that is essential for the control of the cell cycle at the G1/S (start) transition. Cyclin E1 is present in testis and placenta and weakly expressed on bronchial epithelial cells. Mutations leads to overexpression of this gene and have been observed in many tumors.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

CCNE, G1/S-specific cyclin-E1, CCNE1

Detailed product information

Technical specifications

CloneREAL1136
Clonalitymonoclonal
Isotype controlControl Antibody
Hosthuman cell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCyclin E1
Alternative names of antigenCCNE, G1/S-specific cyclin-E1, CCNE1
Distribution of antigenepithelial cells, testicle, placenta

Resources for Cyclin E1 Antibody, anti-human, REAdye_lease™

Certificates

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References for Cyclin E1 Antibody, anti-human, REAdye_lease™

Publications

  1. Koff, A. et al. (1992) Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science 257(5077): 1689-1694
  2. Ohtsubo, M. et al. (1995) Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol. Cell. Biol. 15(5): 2612-2624
  3. Nakayama, K. et al. (2016) CCNE1 amplification is associated with aggressive potential in endometrioid endometrial carcinomas. Int. J. Oncol. 48(2): 506-516
  4. Turner, N. C. et al. (2019) Cyclin E1 Expression and Palbociclib Efficacy in Previously Treated Hormone Receptor-Positive Metastatic Breast Cancer. J. Clin. Oncol. 37(14): 1169-1178

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