Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:

Specifications for CrkL pY207 Antibody, anti-human, REAfinity™


Clone REA500 recognizes the human CrkL antigen phosphorylated at tyrosine 207 (pY207). CRKL is a member of adaptor proteins that participate in signal transduction in response to both extracellular and intracellular stimuli, such as growth factors, cytokines, and the oncogenic BCR-ABL fusion protein. CRKL consists of an N-terminal Src homology 2 (SH2) domain followed by two SH3 domains (SH2-SH3N-SH3C). The SH2 domain of CRKL binds to phosphorylated Y-x-x-P motif present in many docking proteins, such as BCAR1, Paxillin, and GAB, whereas the SH3N domain binds to proline-rich P-x-x-P-x-K motif-containing proteins, such as Son of Sevenless (SOS), RAPGEF1, p85, ABL1, and BCR-ABL. Through these interactions, CRKL facilitates the timely and localized formation of protein complexes required for signal transduction in many biological processes including cell proliferation, survival, adhesion, and migration. CRKL is preferentially expressed in hematopoietic cells. Y207 in CRKL represents the major
in vivo
phosphorylation site. It is phosphorylated in hematopoietic cells that express the BCR-ABL fusion protein. Phosphorylation of Y207 provides a binding site for the CRKL SH2 domain and potentially for other SH2-containing proteins.
Additional information: Clone REA500 displays negligible binding to Fc receptors.

Alternative names


Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
AntigenCrkL pY207
Alternative names of antigenCrk-like
Molecular mass of antigen [kDa]34
Entrez Gene ID1399
RRIDAB_2651458, AB_2651459, AB_2651460, AB_2651461, AB_2651462, AB_2651457

Resources for CrkL pY207 Antibody, anti-human, REAfinity™


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References for CrkL pY207 Antibody, anti-human, REAfinity™


  1. ten Hoeve, J. et al. (2002) Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol. Cell. Biol. 16: 5662-5668
  2. de Jong, R. et al. (1997) Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site. Oncogene 14(5): 507-513
  3. Park, T. J. et al. (2014) Essential roles of Crk and CrkL in fibroblast structure and motility. Oncogene 33(43): 5121-5132

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