Clone:
REAL935
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
Gap junction alpha-1 protein, Connexin-43, Cx43, Gap junction 43 kDa heart protein, GJAL, GJA1

Specifications for Connexin 43 (GJA1) Antibody, anti-human, REAdye_lease™

Overview

Clone REAL935 is an antibody fragment derived from the full Connexin 43 (GJA1) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL935 recognizes Connexin 43, a transmembrane protein also known as GJA1 or GJAL, which is one of the gap junction proteins in vertebrates expressed in heart and fetal cochlea, granulosa cells, astrocytes, and also in human astrocytomas and in the astroglial component of glioneuronal tumors. A gap junction consists of two connexons, which has six connexin subunits. Connexons from two different cells form a continuous channel that ensures the direct exchange of molecules. Thus, they contribute to autocrine and paracrine pathways and play an important role in many physiological processes, e.g. in embryonic development, the transmission of excitation in the heart muscle, activation of intracellular signaling pathways and for cell-cell adhesion. Connexin 43 is especially involved in embryonic development, inflammation and spermatogenesis and in muscle contractions. Aberrant expression of Connexin 43 is associated with cancer recurrence and metastatic spread.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Gap junction alpha-1 protein, Connexin-43, Cx43, Gap junction 43 kDa heart protein, GJAL, GJA1

Detailed product information

Technical specifications

CloneREAL935
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenConnexin 43 (GJA1)
Alternative names of antigenGap junction alpha-1 protein, Connexin-43, Cx43, Gap junction 43 kDa heart protein, GJAL, GJA1
Distribution of antigenastrocytes, tumor cells, heart, fetal tissue

Resources for Connexin 43 (GJA1) Antibody, anti-human, REAdye_lease™

Certificates

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References for Connexin 43 (GJA1) Antibody, anti-human, REAdye_lease™

Publications

  1. Aronica, E. et al. (2001) Expression of connexin 43 and connexin 32 gap-junction proteins in epilepsy-associated brain tumors and in the perilesional epileptic cortex. Acta Neuropathologica 101(5): 449-459
  2. Boucher,J. et al. (2018) Connexins, important players in the dissemination of prostate cancer cells. Biochim Biophys Acta Biomembr. 1860(1): 202-215
  3. Bonacquisti, E. E. et al. (2019) Connexin 43 (Cx43) in cancer: Implications for therapeutic approaches via gap junctions. Cancer Lett. 442: 439-444
  4. Aasen, T. et al. (2019) Connexins in cancer: bridging the gap to the clinic . Oncogene 38(23): 4429-4451
  5. Al Deen, N. N. et al. (2019) Connexin43 as a Tumor Suppressor: Proposed Connexin43 mRNA-circularRNAs-microRNAs Axis Towards Prevention and Early Detection in Breast Cancer. Front Med (Lausanne) 6: 192

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