Clone:
REA455
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MC, FC
Alternative names:
Cmklr1, CHEMERINR, Dez, RVER1

Specifications for ChemR23 (CMKLR1) Antibody, anti-human, REAfinity™

Overview

Clone REA455 recognizes the human G-protein–coupled receptor ChemR23 antigen, a multi-pass membrane protein which is also known as chemokine-like receptor 1 (CMKLR1). ChemR23 is expressed by leukocyte populations such as macrophages, immature myeloid and plasmacytoid dendritic cells, as well as on a subset of natural killer (NK) cells. Its natural ligand, chemerin, is a small protein isolated and identified from human inflammatory fluids which acts as a chemoattractant agent for leukocytes expressing ChemR23. Activation of ChemR23 results in intracellular calcium release, inhibition of cAMP accumulation, and phosphorylation of ERK-1/ERK-2 MAP kinases. Chemerin and ChemR23 are involved in the recruitment of NK and dendritic cells (DCs) into tissues in several human inflammatory diseases. They also participate to the regulation of adipocyte metabolism.
Additional information: Clone REA455 displays negligible binding to Fc receptors.

Alternative names

Cmklr1, CHEMERINR, Dez, RVER1

Detailed product information

Technical specifications

CloneREA455
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenChemR23 (CMKLR1)
Alternative names of antigenCmklr1, CHEMERINR, Dez, RVER1
Molecular mass of antigen [kDa]42
Distribution of antigenleukocytes, macrophages, dendritic cells, NK cells
Entrez Gene ID1240
RRIDAB_2857743, AB_2857737, AB_2651405, AB_2651406, AB_2801899

Resources for ChemR23 (CMKLR1) Antibody, anti-human, REAfinity™

Certificates

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References for ChemR23 (CMKLR1) Antibody, anti-human, REAfinity™

Publications

  1. Samson, M. et al. (1998) ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains. Eur. J. Immunol. 28(5): 1689-1700
  2. Methner, A. et al. (1997) A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development. Biochem. Biophys. Res. Commun. 233(2): 336-342
  3. Bondue, B. et al. (2012)
    The chemerin/ChemR23 system does not affect the pro-inflammatory response of mouse and human macrophages
    ex vivo
    .
    PLoS One 7(6): 400-443

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