MACS GMP Recombinant Human TPO

MACS GMP Recombinant Human TPO

Thrombopoietin (TPO), also termed megakaryocyte growth and development factor (MGDF), is a glycoprotein hormone and the major stimulator of megakaryopoiesis and platelet production. It promotes the proliferation of hematopoietic stem cells, primitive progenitors, megakaryocytes, and platelets.
MACS GMP Recombinant Human TPO is designed for
ex vivo
cell culture processing. No animal- or human-derived materials were used for the manufacture of this product. The product is lyophilized without carrier protein or preservatives.

Disclaimer

MACS GMP Products are for research use and
ex vivo
cell culture processing only, and are not intended for human
in vivo
applications. For regulatory status in the USA, please contact your local representative.

Background information

TPO is expressed in liver, kidney, spleen, lung, bone marrow, and brain. The TPO receptor is a product of the proto-oncogene
c-mpl
and displays homology with type I cytokine receptor superfamily members. The receptor is present mainly on hematopoietic stem cells, megakaryocytic progenitors, megakaryocytes, and platelets.

Applications

MACS GMP Recombinant Human TPO can be used for a variety of applications, including the expansion
2,3
and the viral transduction
4,5
of hematopoietic stem and progenitor cells derived from bone marrow, peripheral blood cells, and cord blood, or the
in vitro
differentiation of megakaryocytes
6
.

Quality statement

MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.

Biological activity

  • The specific activity is determined by proliferation assay according to Page
    et al.1
    using M07e cells. The proliferation assay was calibrated with the Non WHO Reference Material for human TPO (NIBSC code 03/124) provided by the National Institute for Biological Standards and Control.
  • Specific activity: ≥ 1×
    10
    7
    U/mg
  • Certificates of Analysis (CoA)

    Please follow this
    link
    to search for certificates by lot number.
Product options: 1

Product information

Size
Order no.
Price

MACS GMP Recombinant Human TPO

  • E. coli
  • For research use and
    ex vivo
    cell processing only
50 µg
170-076-134
EUR 857,00 

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