MACS GMP Recombinant Human IL-2

MACS GMP Recombinant Human IL-2

Interleukin 2 (IL-2), a potent lymphoid cell growth factor, plays an important role in both the activation and maintenance of immune responses and in lymphocyte development. IL-2 promotes, for instance, proliferation and differentiation of T cells, NK cells, and B cells.
MACS GMP Recombinant Human IL-2 is designed for
ex vivo
cell culture processing. No animal- or human-derived materials were used for the manufacture of this product, unless otherwise stated in the respective Certificate of Origin. The product is lyophilized without carrier protein or preservatives.

Disclaimer

MACS GMP Products are for research use and
ex vivo
cell culture processing only, and are not intended for human
in vivo
applications. For regulatory status in the USA, please contact your local representative.

Background information

IL-2 is a typical four α-helix bundle cytokine and is produced by activated T cells, especially the CD4
+
T helper cell population. IL-2 signals through a receptor complex consisting of IL-2 receptor α-chain (CD25), β-chain, and common γ-chain.

Applications

MACS GMP Recombinant Human IL-2 can be used for a variety of applications, including the
ex vivo
activation and expansion of T cells, e.g., antigen-specific cytotoxic T lymphocytes
2,3
or regulatory T cells
4
or the
ex vivo
stimulation of NK cells
5,6
.

Quality statement

MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.

Biological activity

  • The specific activity is determined by proliferation assay according to Gearing and Bird
    1
    using CTLL-2 cells. The proliferation assay was calibrated with the 2nd international standard for human IL-2 (NIBSC code 86/500) provided by the National Institute for Biological Standards and Control.
  • Specific activity: ≥ 1×
    10
    6
    IU/mg
  • Certificates of Analysis (CoA)

    Please follow this
    link
    to search for certificates by lot number.
Product options: 3

Product information

Size
Order no.
Price

MACS GMP Recombinant Human IL-2

  • E. coli
  • For research use and
    ex vivo
    cell processing only
25 µg
170-076-148
EUR 182,00 

MACS GMP Recombinant Human IL-2

  • E. coli
  • For research use and
    ex vivo
    cell processing only
100 µg
170-076-146
EUR 463,00 

MACS GMP Recombinant Human IL-2

  • E. coli
  • For research use and
    ex vivo
    cell processing only
500 µg
170-076-147
EUR 1.561,00