MACS GMP PepTivator® AdV5 Hexon

MACS GMP PepTivator
®
AdV5 Hexon

The MACS GMP PepTivator AdV5 Hexon is a peptide pool that consists mainly of 15-mer peptides with eleven amino-acid overlap. It has been developed for efficient
in vitro
stimulation and subsequent isolation AdV5 hexon-specific CD4
+
and CD8
+
T cells.

Disclaimer

MACS GMP Products are for research use and
ex vivo
cell culture processing only, and are not intended for human
in vivo
applications. For regulatory status in the USA, please contact your local representative.

Background information

Human adenoviruses (AdV) are ubiquitous lytic DNA viruses, consisting of multiple serotypes and subspecies. AdV infections are associated with significant morbidity and mortality after hematopoetic stem cell transplantations.
The hexon protein is one of the three major proteins of the viral capsid and an immunodominant target antigen for CD4
+
and CD8
+
T cells that is conserved between the serotypes and subspecies.

Applications

Antigen-specific T cells play a critical role in the regulation of immune responses and the elimination of virus-infected or malignant cells in the human body. Adoptive transfer of clinical-grade hexon-specific CD4
+
and CD8
+
T cells is a valuable tool for the treatment of AdV infections after hematopoietic stem cell transplantation (SCT)
1
.
The
in vitro
stimulation of hexon-specific CD4
+
and CD8
+
T cells with MACS GMP PepTivator AdV5 Hexon causes the production of the effector cytokine IFN-gamma. The secretion of IFN-gamma then permits the enrichment of hexon-specific effector/memory T cells with the use of the CliniMACS Cytokine Capture System (IFN-gamma).

Quality statement

MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
  • Certificates of Analysis (CoA)

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Video

ISCT Webinar: CliniMACS Prodigy – Mastering the complexity of cell processing

This webinar introduces the CliniMACS Prodigy System; and outlines the Cytokine Capture System (IFN-gamma) process for the manufacturing of multi-antigen-specific T cells. The webinar was produced by the International Society for Cellular Therapy, ISCT.

Product options: 1

Product information

Size
Order no.
Price

MACS GMP PepTivator AdV5 Hexon

  • For research use and
    ex vivo
    cell processing only
for
stimulation of
10
9
cells
170-076-106
EUR 2.495,00 

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