MACS GMP CD3 pure

MACS GMP CD3 pure

Clone: OKT3
MACS GMP CD3 pure is a GMP-grade soluble CD3 (OKT3) antibody for
ex vivo
T cell activation.

Disclaimer

MACS GMP Products are for research use and
ex vivo
cell culture processing only, and are not intended for human
in vivo
applications. For regulatory status in the USA, please contact your local representative.

Background information

The CD3 antibody (OKT3) recognizes the human CD3 antigen which is expressed on mature T cells, thymocytes and NKT cells. CD3 is associated with the T cell receptor (TCR) and induces the signaling cascade for effector functions of the T cell.
Activation and proliferation of T cells can be induced by interaction of the T cell receptor (TCR) with peptide-MHC complexes expressed on the surface of antigen presenting cells (APC). T cell activation can also be achieved by agonistic stimulation with the CD3 antibody binding to the TCR complex.

Applications

The antibody is suitable for
ex vivo
T cell activation and expansion and is already established in a variety of clinical protocols for
ex vivo
T cell stimulation. For example, the transduction of T cells with viral vectors requires the previous activation, which can be achieved by stimulation with CD3 antibody
1,2
. Furthermore, T cell subsets, such as tumor infiltrating lymphocytes (TILs) can be expanded
3
, or T cells polyclonally activated by CD3 stimulation.
The CD3 antibody can be combined with CD28 antibody, which gives an additional costimulatory stimulus
4
.

Quality statement

MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
  • Certificates of Analysis (CoA)

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    link
    to search for certificates by lot number.
Product options: 2

Product information

Size
Order no.
Price

MACS GMP CD3 pure

  • OKT3
  • For research use and
    ex vivo
    cell processing only
0.2 mg in 1 mL
170-076-124
EUR 440,00 

MACS GMP CD3 pure

  • OKT3
  • For research use and
    ex vivo
    cell processing only
1 mg in 1 mL
170-076-116
EUR 1.104,00 

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