CD44 antibodies

CD44 antibodies

Clone: DB105
DB105 recognizes the CD44 antigen. CD44 is a marker for many types of cancer stem cells (CSC), including breast CSCs that possess higher tumorigenicity and metastatic potential, colorectal, pancreatic, and prostate CSCs. In addition, expression was observed in several cancers as well as on carcinoma cell lines. Here, CD44 plays a role in cancer cell migration and matrix adhesion in response to a cellular microenvironment, thus enhancing cellular aggregation and tumor cell growth. CD44 is also expressed on mesodermal cells, such as hematopoietic, fibroblastic, and glial cells.

Applications

Reagent can be used for immunophenotyping by flow cytometry. Abnormal numbers of cells expressing this antigen or aberrant expression levels of the antigen can be expected in some disease states. It is important to understand the normal expression pattern for this antigen and its relationship to expression of other relevant antigens in order to perform appropriate analysis.
Expression of CD44 may be used as aid to diagnostic in the characterization of samples from individuals suspected with hematologic neoplasia.

Alternative Names

CD44s, EMCR III, H-CAM, Pgp-1

Technical specifications

  • Antigen: CD44
  • Clone: DB105
  • Isotype: mouse IgG1
  • Alternative names of antigen: CD44s, EMCR III, H-CAM, Pgp-1
  • Molecular mass of antigen [kDa]: 79
  • Distribution of antigen: bone marrow, cancer stem cells, CNS cells, endothelial cells, epithelial cells, kidney, leukocytes, lymphocytes, mesenchymal stem cells, myeloid cells, plasma cells, ES and iPS cells, red blood cells, skeletal muscle, skin, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC
  • Certificates of Analysis (CoA)

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Product options: 1

Product information

Size
Order no.
Price

CD44-FITC

  • DB105
  • CE–IVD
for 50
tests
170-078-029
EUR 350,00