CD3 antibodies

CD3 antibodies

Clone: REA613
REA613 recognizes the human CD3 antigen, a single-pass type I membrane protein, also known as Leu4. CD3 is present on mature human T cells, thymocytes, a subset of NK cells, and on Purkinje cells in cerebellum. It is associated with the T cell receptor (TCR) and is responsible for its signal transduction. The CD3 antigen is a complex of five invariable chains: γ, δ, ε, ζ, and η. The epitope recognized by the antibody is located on the ε-chain of the CD3 complex.
Additional information: Clone REA613 displays negligible binding to Fc receptors.

Applications

Reagent can be used for immunophenotyping by flow cytometry. Abnormal numbers of cells expressing this antigen or aberrant expression levels of the antigen can be expected in some disease states. It is important to understand the normal expression pattern for this antigen and its relationship to expression of other relevant antigens in order to perform appropriate analysis.
Expression of CD3 may be used as aid to diagnostic in the characterization of samples from individuals suspected with hematologic neoplasia.

Alternative Names

T3, CD3-epsilon, CD3e, Leu4, T-cell surface antigen T3/Leu-4 epsilon chain, T3E, IMD18, TCRE

Technical specifications

  • Antigen: CD3
  • Clone: REA613
  • Isotype: recombinant human IgG1
  • Alternative names of antigen: T3, CD3-epsilon, CD3e, Leu4, T-cell surface antigen T3/Leu-4 epsilon chain, T3E, IMD18, TCRE
  • Molecular mass of antigen [kDa]: 21
  • Distribution of antigen: NK cells, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE
  • Certificates of Analysis (CoA)

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Product options: 2

Product information

Size
Order no.
Price

CD3-FITC

  • REA613
  • CE–IVD
for 100
tests
170-078-070
EUR 441,00 

CD3-PE

  • REA613
  • CE–IVD
for 100
tests
170-078-071
EUR 530,00