CD203c antibodies

CD203c antibodies

Clone: FR3-16A11
Clone FR3-16A11 recognizes CD203c, a glycosylated type II transmembrane molecule that belongs to the family of ecto-nucleotide pyrophosphatase/ phosphodiesterase (E-NPP3) enzymes. Among hematopoietic cells, expression of CD203c is restricted to basophils, mast cells and their precursors, and has been described as specific for this lineage. Protein and/or mRNA expression of CD203c has also been found in solid tissues such as uterus or prostate. Basophils and mast cells are key producers of mediators that drive the onset of inflammatory responses, e.g. in allergy. Allergen challenge leads to a rapid up-regulation of activation markers such as CD203c or CD63. Due to its restricted expression pattern, CD203c is discussed as a specific marker to monitor the allergen-induced activation of basophils, e.g. in flow cytometric basophil activation tests of the peripheral blood.

Applications

Reagent can be used for immunophenotyping by flow cytometry. Abnormal numbers of cells expressing this antigen or aberrant expression levels of the antigen can be expected in some disease states. It is important to understand the normal expression pattern for this antigen and its relationship to expression of other relevant antigens in order to perform appropriate analysis.
Expression of CD203c may be used as aid to diagnostic in the characterization of samples from individuals suspected with hematologic neoplasia.

Alternative Names

ENPP3, B10, NPP3, PD-IBETA, PDNP3, E-NPP3, PD-1b

Technical specifications

  • Antigen: CD203c
  • Clone: FR3-16A11
  • Isotype: mouse IgG1κ
  • Alternative names of antigen: ENPP3, B10, NPP3, PD-IBETA, PDNP3, E-NPP3, PD-1b
  • Molecular mass of antigen [kDa]: 100
  • Distribution of antigen: mast cells, basophils, myeloid cells, liver, pancreas, small intestine
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Certificates of Analysis (CoA)

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Product information

Size
Order no.
Price

CD203c-PE

  • FR3-16A11
  • CE–IVD
for 100
tests
170-078-043
EUR 530,00