CD16 antibodies

CD16 antibodies

Clone: REA423
Clone REA423 recognizes the human CD16 antigen, a single-pass type I membrane protein which is also known as low affinity immunoglobulin gamma Fc region receptor III (FcRIII). CD16 is a 50–80 kDa glycoprotein that is expressed in two different isoforms. The transmembrane form is found on human NK cells, macrophages, and mast cells, while the glycosylphosphatidylinositol (GPI)-linked form is present on neutrophils. The human CD16 antigen is a low-affinity receptor for aggregated IgG. The transmembrane form plays a role in signal transduction, NK cell activation, and antibody-dependent cellular cytotoxicity. Clone REA423 recognizes both the extracellular domain of the transmembrane form as well as the GPI-linked form of the human CD16 antigen. CD16 is expressed on the majority of rhesus monkey NK cells and on a subset of monocytes but not on granulocytes.
Additional information: Clone REA423 displays negligible binding to Fc receptors.

Applications

Reagent can be used for immunophenotyping by flow cytometry. Abnormal numbers of cells expressing this antigen or aberrant expression levels of the antigen can be expected in some disease states. It is important to understand the normal expression pattern for this antigen and its relationship to expression of other relevant antigens in order to perform appropriate analysis.
Expression of CD16 may be used as aid to diagnostic in the characterization of samples from individuals suspected with hematologic neoplasia.

Alternative Names

FCGR3A, FCGR3B, FcR-10, IGFR3, IMD20, FcRII

Technical specifications

  • Antigen: CD16
  • Clone: REA423
  • Isotype: recombinant human IgG1
  • Alternative names of antigen: FCGR3A, FCGR3B, FcR-10, IGFR3, IMD20, FcRII
  • Molecular mass of antigen [kDa]: 48
  • Distribution of antigen: NK cells, monocytes, granulocytes, dendritic cells, macrophages, mast cells, neutrophils
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
Product options: 3

Product information

Size
Order no.
Price

CD16-FITC

  • REA423
  • CE–IVD
for 100
tests
170-078-052
EUR 441,00 

CD16-PE

  • REA423
  • CE–IVD
for 100
tests
170-078-088
EUR 530,00 

CD16-APC

  • REA423
  • CE–IVD
for 100
tests
170-078-053
EUR 530,00