CD117 antibodies

CD117 antibodies

Clone: A3C6E2
A3C6E2 recognizes human CD117, also known as c-kit or SCF receptor. It is a 145 kDa receptor tyrosine kinase that is involved in stem cell signaling, activation, and proliferation. The CD117 antigen is expressed on about 1–3% of mononuclear cells from peripheral blood mononuclear cells (PBMCs) or cord blood, and on up to 10% of bone marrow cells. CD117 is further expressed on basophils, myeloid dendritic cells, TCRα/β
+
T cells, CD19
+
B cells, and CD56
+
NK cells, as well as on mast cells, melanocytes, and AML (acute myeloid leukemia) blasts.

Applications

Reagent can be used for immunophenotyping by flow cytometry. Abnormal numbers of cells expressing this antigen or aberrant expression levels of the antigen can be expected in some disease states. It is important to understand the normal expression pattern for this antigen and its relationship to expression of other relevant antigens in order to perform appropriate analysis.
Expression of CD117 may be used as aid to diagnostic in the characterization of samples from individuals suspected with hematologic neoplasia.

Alternative Names

c-kit, PBT, SCFR, KIT

Technical specifications

  • Antigen: CD117
  • Clone: A3C6E2
  • Isotype: mouse IgG1κ
  • Alternative names of antigen: c-kit, PBT, SCFR, KIT
  • Molecular mass of antigen [kDa]: 107
  • Distribution of antigen: B cells, bone marrow, brain, cancer cells, endothelial cells, fibroblasts, hematopoietic stem cells, kidney, leukemia cells, liver, lung, mast cells, megakaryocytes, myeloid cells, NK cells, red blood cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Certificates of Analysis (CoA)

    Please follow this
    link
    to search for certificates by lot number.
Product options: 2

Product information

Size
Order no.
Price

CD117-PE

  • A3C6E2
  • CE–IVD
for 100
tests
170-078-037
EUR 530,00 

CD117-APC

  • A3C6E2
  • CE–IVD
for 100
tests
170-078-038
EUR 530,00