CD45RA antibodies

CD45RA antibodies

Clone: T6D11
T6D11 recognizes the human CD45RA antigen which is expressed on naive CD4
+
and CD8
+
T cells as well as on CD8
+
effector T cells. CD45RA is also present on subsets of B and NK cells as well as on plasmacytoid dendritic cells. The CD45RA antibody recognizes the 220 kDa isoform of the leukocyte common antigen (LCA), a transmembrane tyrosine phosphatase.

Technical specifications

  • Antigen: CD45RA
  • Clone: T6D11
  • Isotype: mouse IgG2b
  • Molecular mass of antigen [kDa]: 145
  • Distribution of antigen: B cells, monocytes, NK cells, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C (36–46 °F). Do not freeze.
  • Available conjugates: VioBlue, APC
  • Selected references

    1. Braun, T. et al. (2012)
      Effector CD4
      +
      CD45RA
      CD25
      bright
      Foxp3
      bright
      regulatory T cell (eTreg) distribution is significantly impaired in chronic myelomonocytic leukemia (CMML) and correlates with TET 2 mutational status.
      Blood 120: 2808-2808
    2. Baba, N. et al. (2010)
      Interplay between CD45RA
      +
      regulatory T cells and TNF-α in the regulation of human Tʜ17 differentiation.
      Int. Immunol. 22: 237-244
    3. Wood BL et al. (2007) 2006 Bethesda International Consensus recommendations on the immunophenotypic analysis of hematolymphoid neoplasia by flow cytometry: optimal reagents and reporting for the flow cytometric diagnosis of hematopoietic neoplasia. Cytometry B Clin. Cytom. 72: 14-22
    4. Cantisan, S. et al. (2010)
      CD45RA expression on HCMV-specific effector memory CD8
      +
      T cells is associated with the duration and intensity of HCMV replication after transplantation.
      Clin. Immunol. 137(1): 81-88
    5. Stelzer GT et al. (1997) U.S.-Canadian consensus recommendations on the immunophenotypic analysis of hematologic neoplasia by flow cytometry: standardization and validation of laboratory procedures. Cytometry 30(5): 214-230
    6. Rothe, G et al. (2012) Consensus protocol for the flow cytometric Immunophenotyping of hematopoietic malignancies. Leukemia 10(5): 877-895
    7. van Dongen, J. J. M. et al. (2012) EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes. Leukemia 26(9): 1908-1975
    8. Clinical and Laboratory Standards Institute (CLSI) (2007) Clinical Flow Cytometric Analysis of Neoplastic Hematolympoid Cells, CLSI document H43-A2 (ISBN 1-56238-635-2) CLSI; Approved Guideline - Second Edition
    9. Clinical and Laboratory Standards Institute (CLSI) (2007) Enumeration of immunologically defined cell populations by flow cytometry, CLSI document H42-A2 (ISBN 1-56238-640-9) CLSI; Approved Guideline - Second Edition
  • Certificates

    Please follow this
    link
    to search for Certificates of Analysis (CoA) by lot number.
Product options: 2
170-081-003

CD45RA-APC

1 mL
EUR 420,00 
170-081-080

CD45RA-VioBlue

1 mL
EUR 475,00