Clone:
REAL115
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
Leu-2, CD8a, MAL, p32, Cd8b1, LY3, Lyt3, P37, Ly-2

Specifications for CD8 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL115 is an antibody fragment derived from the full CD8 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL115 recognizes the human CD8 antigen, a cell-surface glycoprotein also known as Leu-2 or CD8a. CD8 is strongly expressed on human cytotoxic T cells and thymocytes, on a subset of NK cells, and also expressed in T cell lymphoblastic lymphoma. The CD8 antigen is a disulfide-linked dimer that exists either as a CD8a homodimer or as a CD8α/β heterodimer. CD8 acts as a coreceptor for the T cell receptor and binds to the MHC Class I molecules. CD8 is involved in T cell development and activation of mature T cells.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Leu-2, CD8a, MAL, p32, Cd8b1, LY3, Lyt3, P37, Ly-2

Detailed product information

Technical specifications

CloneREAL115
Clonalitymonoclonal
Isotype controlControl Antibody
Hosthuman cell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD8
Alternative names of antigenLeu-2, CD8a, MAL, p32, Cd8b1, LY3, Lyt3, P37, Ly-2
Distribution of antigenT cells, NK cells, thymocytes, other

Resources for CD8 Antibody, anti-human, REAdye_lease™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD8 Antibody, anti-human, REAdye_lease™

Publications

  1. Devine, L. et al. (1999) Orientation of the Ig domains of CD8 alpha beta relative to MHC class I. J. Immunol. 162(2): 846-851
  2. Gao, G. F. et al. (2000) Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor. Immunol. Today 21(12): 630-636

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