Clone:
REAL1172
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
CALJA, E5NT, NT, Nt5, NTE, eN, eNT

Specifications for CD73 (NT5E) Antibody, anti-human, REAdye_lease™

Overview

Clone REAL1172 is an antibody fragment derived from the full CD73 (NT5E) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1172 recognizes the human CD73 (NT5E) antigen, which is a 70 kDa membrane-bound enzyme that catalyzes the conversion of AMP to bioactive adenosine at neutral pH. This glycoprotein is also called ecto-5’-nucleotidase. CD73 is present on subsets of T and B lymphozytes, follicular dendritic cells, endothelial cells, and marrow stromal cells (MSCs). CD73 (NT5E) acts as an inhibitory immune checkpoint molecule, expressed on cancer cells. It has been associated with poor survival and recurrence in patients with breast and ovarian cancer. In addition to the enzymatic role of CD73, it is an adhesion molecule. It mediates the interaction between endothelial cells and lymphocytes and takes a role in cell migration of normal and neoplastic cells.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

CALJA, E5NT, NT, Nt5, NTE, eN, eNT

Detailed product information

Technical specifications

CloneREAL1172
Clonalitymonoclonal
Isotype controlControl Antibody
Hosthuman cell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD73 (NT5E)
Alternative names of antigenCALJA, E5NT, NT, Nt5, NTE, eN, eNT
Distribution of antigenB cells, dendritic cells, endothelial cells, epithelial cells, lymphocytes, T cells, mesenchymal stem cells

Resources for CD73 (NT5E) Antibody, anti-human, REAdye_lease™

Certificates

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References for CD73 (NT5E) Antibody, anti-human, REAdye_lease™

Publications

  1. Pittenger, M. F. et al. (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284: 143-147
  2. Thomson, L. F. et al. (1990) Production and characterization of monoclonal antibodies to the glycosyl Tissue Antigens 35: 9-19
  3. Turcotte, M. et al. (2015) CD73 is associated with poor prognosis in high-grade serous ovarian cancer. Cancer Res. 75(21): 4494-4503

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