Clone:
REA311
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
T-cell differentiation antigen CD6

Specifications for CD6 Antibody, anti-mouse, REAfinity™

Overview

Clone REA311 recognizes the murine CD6 antigen, a Single-pass type I membrane protein which is expressed on most CD4+CD8+ double-positive, CD4+ or CD8+ single-positive thymocytes, and at highest levels on mature CD3+ thymocytes. In marked contrast to human CD6, mouse CD6 has a long cytoplasmic tail that is not closely related to other proteins. CD6 functions as an adhesion molecule as well as costimulatory molecule for TCR-mediated T cell activation. In thymocytes that express heterogeneous TCR, CD6 increases occur as double-positive thymocytes are selected to a single-positive stage. In contrast, in thymocytes from TCR transgenic mice, CD6 is barely increased following selection, suggesting that as functional avidity increases, requirements for CD6-dependent co-stimulation decrease. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection.
Additional information: Clone REA311 displays negligible binding to Fc receptors.

Alternative names

T-cell differentiation antigen CD6

Detailed product information

Technical specifications

CloneREA311
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD6
Alternative names of antigenT-cell differentiation antigen CD6
Molecular mass of antigen [kDa]71
Distribution of antigenT cells, thymocytes
Entrez Gene ID12511
RRIDAB_2658796, AB_2658797, AB_2658798, AB_2658799, AB_2658800, AB_2658801, AB_2658802, AB_2658803, AB_2658804, AB_2658805, AB_2876984

References for CD6 Antibody, anti-mouse, REAfinity™

Publications

  1. Robinson, W. H. et al. (1995) Identification of a mouse protein homologous to the human CD6 T cell surface protein and sequence of the corresponding cDNA. J. Immunol. 155(10): 4739-4748
  2. Singer, N. G. et al. (2002) CD6: expression during development, apoptosis and selection of human and mouse thymocytes. Int. Immunol. 14(6): 585-597
  3. Whitney, G. et al. (1995) Cloning and characterization of murine CD6. Mol. Immunol. 32(1): 89-92

Related products for
CD6 Antibody, anti-mouse, REAfinity™

2 products available