Clone:
REAL242
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
VLA-6, ITGA6B, VLA-6α, α6 integrin, CD49fB

Specifications for CD49f Antibody, anti-mouse, REAdye_lease™

Overview

Clone REAL242 is an antibody fragment derived from the full CD49f antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL242 recognizes the CD49f antigen, a 120kD Single-pass type I membrane protein which is also known as Integrin alpha-6 (ITGA6). Integrins are integral cell-surface proteins composed of an α chain and a β chain and are involved in cell adhesion as well as cell-surface mediated signaling. CD49f associates with integrin β1 chain (CD29) to form VLA-6 and with integrin β4 chain (CD104) to form the α6 β4 complex, which plays a critical structural role in the hemidesmosome and constitutes a receptor for laminin in epithelial cells. CD49f is furthermore expressed on T cells, monocytes, platelets, endothelial cells, trophoblasts of placenta, and spermatogonial stem cells.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

VLA-6, ITGA6B, VLA-6α, α6 integrin, CD49fB

Detailed product information

Technical specifications

CloneREAL242
Clonalitymonoclonal
Isotype controlControl Antibody
Hosthuman cell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD49f
Alternative names of antigenVLA-6, ITGA6B, VLA-6α, α6 integrin, CD49fB
Distribution of antigenepithelial cells, lymphocytes, megakaryocytes, monocytes, platelets, T cells, stem cells, cancer stem cells, hematopoietic stem and progenitor cells, ES and iPS cells, thymocytes, brain, kidney, liver, lung, ovary, spleen

Resources for CD49f Antibody, anti-mouse, REAdye_lease™

Certificates

Please follow this
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to search for Certificates of Analysis (CoA) by lot number.

References for CD49f Antibody, anti-mouse, REAdye_lease™

Publications

  1. Hemler, M. E. et al. (1988) Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures. J. Biol. Chem. 263: 7660-7665
  2. Carter, W. G. et al. (1990) Distinct functions for integrins α 3 β 1 in focal adhesions and α 6 β 4/bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes. J. Cell Biol. 111: 3141-3154
  3. Aumailley, M. et al. (1990) Antibody to integrin α 6 subunit specifically inhibits cell-binding to laminin fragment 8. Exp. Cell Res. 188(1): 55-60
  4. Hynes, R. O. (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110(6): 673-687
  5. Izadyarz, F. et al. (2011) Identification and characterization of repopulating spermatogonial stem cells from the adult human testis. Hum. Reprod. 26(6): 1296-1306

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