Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
ITGA4, Itga4B, VLA-4α, Integrin alpha-4

Specifications for CD49d Antibody, anti-mouse, REAfinity™


Clone REA807 recognizes the mouse CD49d antigen, a 150 kDa integrin family member, also known as integrin α4 chain. Integrins are cell-surface receptors, expressed as heterodimers essential in various processes mediating intercellular or cell-matrix interaction. CD49d associates non-covalently with the integrin ß or ß1 (CD29) forming the complex VLA4, which is expressed on peripheral lymphocytes, thymocytes, eosinophils, basophils, mast cells, dendritic cells, and monocytes. VLA4 plays a critical role in adhesion and migration of cells into tissues by binding to its ligand VCAM-1 (CD106). Together with the ß7 integrin, CD49d forms the heterodimer LPAM-1, which is a ligand for the mucosal vascular addressin (MAdCAM-1).
Additional information: Clone REA807 displays negligible binding to Fc receptors.

Alternative names

ITGA4, Itga4B, VLA-4α, Integrin alpha-4

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Alternative names of antigenITGA4, Itga4B, VLA-4α, Integrin alpha-4
Molecular mass of antigen [kDa]111
Distribution of antigenB cells, dendritic cells, Langerhans cells, lymphocytes, macrophages, mast cells, monocytes, myeloid leukemia cells, NK cells, red blood cells, T cells, basophils, eosinophils, thymocytes, cardiac muscle, placenta, skeletal muscle, smooth muscle
Entrez Gene ID16401
RRIDAB_2658514, AB_2658515, AB_2658516, AB_2658517, AB_2658518, AB_2751062, AB_2751056, AB_2658519, AB_2658520, AB_2658513

Resources for CD49d Antibody, anti-mouse, REAfinity™


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References for CD49d Antibody, anti-mouse, REAfinity™


  1. Berlin, C. et al. (1993) Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 74(1): 185-195
  2. Fogler, W. E. et al. (1996) NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction. J. Immunol. 156(12): 4707-4714

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