Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CD33 antigen, CD33 protein

Specifications for CD33 CAR Detection Reagent, human

Overview

The CD33 CAR Detection Reagent, anti-human, Biotin, REAfinity™ has been developed for the detection of transduced T cells that are engineered to express CD33-specific chimeric antigen receptors (CAR) on the cell surface, which recognize human CD33 antigen. The CD33 CAR Detection Reagent is an antigen based detection reagent conjugated to biotin. It contains a recombinantly expressed fusion protein consisting of the human CD33 extracellular domains and a specifically mutated human IgG1 Fc region. The engineered CD33 CAR T cells can be detected via the recognition of the CD33 protein, and identified by flow cytometry via anti-biotin fluorochromes. The mutated human IgG1 Fc region of the CD33 CAR Detection Reagent abolishes their binding to Fcγ receptors. This allows for background-free analysis and eliminates the need for additional blocking steps, such as using a FcR blocking reagent.

Alternative names

CD33 antigen, CD33 protein

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Specieshuman
AntigenCD33 CAR
Alternative names of antigenCD33 antigen, CD33 protein
Distribution of antigenCAR NK cells, CAR T cells

Resources for CD33 CAR Detection Reagent, human

Certificates

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