Clone:
REAL858
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
BTLA, BTLA1

Specifications for CD272 (BTLA) Antibody, anti-human, REAdye_lease™

Overview

Clone REAL858 is an antibody fragment derived from the full CD272 (BTLA) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL858 recognizes the human CD272 protein, which is also known as BTLA (B and T lymphocyte attenuator) and a member of the immunoglobin superfamily. It has structural similarities to PD-1 (programmed cell death 1) and CTLA-4. Expression is found on T and B cells, macrophages, DCs (dendritic cells), NKT cells, and NK cells, it is not expressed by cancer cells. CD272 functions as a receptor that passes inhibitory signals to suppress the immune response. The activation of CD272 inhibits the function of human CD8
+
cancer-specific T cells.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

BTLA, BTLA1

Detailed product information

Technical specifications

CloneREAL858
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD272 (BTLA)
Alternative names of antigenBTLA, BTLA1
Distribution of antigenB cells, T cells, macrophages, dendritic cells, NK cells, NKT cells, liver
RRIDAB_2857817

Resources for CD272 (BTLA) Antibody, anti-human, REAdye_lease™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD272 (BTLA) Antibody, anti-human, REAdye_lease™

Publications

  1. Derré, L. et al. (2010) BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination. J. Clin. Invest. 120(1): 157-167

Related products for
CD272 (BTLA) Antibody, anti-human, REAdye_lease™

1 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?