CD267 (TACI) Antibody, anti-mouse
Clone:
8F10
Type of antibody:
Primary antibodies
Isotype:
rat IgG2aκ
Applications:
FC
Alternative names:
TNFRSF13B, TACI

Specifications for CD267 (TACI) Antibody, anti-mouse

Overview

Clone 8F10 recognizes CD267, a type III transmembrane protein receptor that binds to APRIL and BAFF and also interacts with heparan sulfate proteoglycans (HSPGs). Expression of CD267 is found on subset of T cells, marzinal zone (MZ) and, B1 B cells. A dual role of TACI has been suggested in regulating B cell activation. TACI
-/-
mice have high number of hyper-reactive B cells, indicating an inhibitory role of TACI. On the other hand, mice lacking TACI are unable to mount normal T-cell independent type 2 (TI-2) immune response and thus suggesting a positive role in promoting B cell activation.

Alternative names

TNFRSF13B, TACI

Detailed product information

Technical specifications

Clone8F10
Clonalitymonoclonal
Isotyperat IgG2aκ
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD267 (TACI)
Alternative names of antigenTNFRSF13B, TACI
Molecular mass of antigen [kDa]27
Distribution of antigenB cells, T cells
Entrez Gene ID57916
RRIDAB_2656775, AB_2656776, AB_2656777, AB_2656778, AB_2656779, AB_2656774

Resources for CD267 (TACI) Antibody, anti-mouse

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD267 (TACI) Antibody, anti-mouse

Publications

  1. Batten, M. et al. (2004) TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma. J Immunol 172: 812-822
  2. Yan, M. et al. (2001) Activation and accumulation of B cells in TACI-deficient mice. Nat Immunol 2(7): 638-643
  3. Mackay, F. et al. (2008) TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties. Cytokine Growth Factor Rev. 19(3–4): 263-276

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