Clone:
REA1196
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
Dpp4, DPP IV, THAM

Specifications for CD26 Antibody, anti-mouse, REAfinity™

Overview

Clone REA1196 recognizes the mouse CD26 antigen, a 220 kDa single-pass type II membrane protein also known as dipeptidyl peptidase 4 (Dpp4) or thymocyte-activating molecule (THAM). CD26 is a multifunctional glycoprotein expressed both as a soluble form in plasma and on the surface of several cell types, including epithelial and endothelial cells. In the immune system CD26 is expressed on thymocytes, activated T cells, B cells, NK cells, and macrophages. It has been involved in T cell costimulation, tumor suppression, and adenosine deaminase binding. In addition, CD26 is a serine protease belonging to a subgroup of prolyl oligopeptidases, whose members specifically cleave off N-terminal dipeptides from proteins having proline or alanine in amino acid position 2. The biological activity of several hormones and chemokines can be abolished by CD26
in vitro
. Thus, CD26 has been implicated in the regulation of immune, inflammatory, nervous, and endocrine functions.
Additional information: Clone REA1196 displays negligible binding to Fc receptors.

Alternative names

Dpp4, DPP IV, THAM

Detailed product information

Technical specifications

CloneREA1196
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD26
Alternative names of antigenDpp4, DPP IV, THAM
Molecular mass of antigen [kDa]87
Distribution of antigenB cells, T cells, NK cells, macrophages, thymocytes
Entrez Gene ID13482
RRIDAB_2801935, AB_2801934

Resources for CD26 Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD26 Antibody, anti-mouse, REAfinity™

Publications

  1. Marguet, D. et al. (2000) Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26. Proc. Natl. Acad. Sci. U.S.A. 97(12): 6874-6879
  2. Marguet, D. et al. (1992) cDNA cloning for mouse thymocyte-activating molecule. A multifunctional ecto-dipeptidyl peptidase IV (CD26) included in a subgroup of serine proteases. J. Biol. Chem. 267(4): 2200-2208
  3. Matteucci, E. et al. (2009) Dipeptidyl peptidase-4 (CD26): knowing the function before inhibiting the enzyme. Curr. Med. Chem. 16(23): 2943-2951

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