Clone:
REA1187
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
BL-CAM, SIGLEC-2, Lyb-8

Specifications for CD22 Antibody, anti-mouse, REAfinity™

Overview

Clone REA1187 recognizes the 150 kDa B cell–restricted glycoprotein CD22 on mice strains having the Lyb-8.2 alloantigen, e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, and SWR. Lyb-8.2 is expressed at mature levels on all B cell subsets. In bone marrow, CD22 is not detectable on pro–B cells, pre–B cells, and emerging IgM
+
B cells. CD22 plays a strong role in cell interactions and B cell activation.
Additional information: Clone REA1187 displays negligible binding to Fc receptors.

Alternative names

BL-CAM, SIGLEC-2, Lyb-8

Detailed product information

Technical specifications

CloneREA1187
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD22
Alternative names of antigenBL-CAM, SIGLEC-2, Lyb-8
Molecular mass of antigen [kDa]94
Distribution of antigenB cells
Entrez Gene ID12483
RRIDAB_2784068, AB_2784065, AB_2784064, AB_2784071, AB_2784070, AB_2784073, AB_2784072, AB_2784075, AB_2784074, AB_2784067, AB_2784066, AB_2784069

References for CD22 Antibody, anti-mouse, REAfinity™

Publications

  1. Symington, F. W. et al. (1982) Lyb-8.2: A new B cell antigen defined and characterized with a monoclonal antibody. Immunogenetics 16(5): 381-391
  2. Law, C. L. et al. (1994) Regulation of lymphocyte activation by the cell-surface molecule CD22. Immunol. Today 15(9): 442-449
  3. Erickson, L. D. et al. (1996) Differential expression of CD22 (Lyb8) on murine B cells. Immunogenetics 8(7): 1121-1129

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