Clone:
REA308
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
IL13RA2, CD213A2, CT19, IL-13R, IL13BP

Specifications for CD213α2 (IL-13Rα2) Antibody, anti-human, REAfinity™

Overview

Clone REA308 recognizes the human CD213α2 antigen, a single-pass type I membrane protein which is also known as interleukin-13 receptor subunit α-2 (IL-13Rα2). CD213α2 is a high affinity receptor for IL-13 that is used only by IL-13 and is quite distinct from CD213α1 (IL-13Rα1) that IL-13 shares with IL-4. CD213α2 is expressed by fibroblasts, smooth muscle cells, keratinocytes, and activated B cells. It has been thought to be a decoy receptor due to its short cytoplasmic tail and it exists on the cell membrane, intracellularly, and in soluble form. Recent reports revealed that membrane CD213α2 may have some signaling capabilities, and soluble CD213α2 is a critical endogenous modulator for IL-13 responses. Additionally, IL-13 signaling via CD213α2 plays a role in tumor immune surveillance.
Additional information: Clone REA308 displays negligible binding to Fc receptors.

Alternative names

IL13RA2, CD213A2, CT19, IL-13R, IL13BP

Detailed product information

Technical specifications

CloneREA308
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD213α2 (IL-13Rα2)
Alternative names of antigenIL13RA2, CD213A2, CT19, IL-13R, IL13BP
Molecular mass of antigen [kDa]42
Distribution of antigenB cells, fibroblasts, keratinocytes, smooth muscle
Entrez Gene ID3598
RRIDAB_2656324, AB_2656325, AB_2656326, AB_2656329, AB_2656330, AB_2656331, AB_2656332, AB_2656333, AB_2656334, AB_2656323

Resources for CD213α2 (IL-13Rα2) Antibody, anti-human, REAfinity™

Certificates

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References for CD213α2 (IL-13Rα2) Antibody, anti-human, REAfinity™

Publications

  1. Andrews, A. L. et al. (2006) IL-13 receptor α2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts. J. Allergy Clin. Immunol. 118(4): 858-865
  2. Tabata, Y. et al. (2007) IL-13 receptor isoforms: breaking through the complexity. Curr. Allergy Asthma Rep. 7(5): 338-345
  3. Strober, W. et al. (2009) The signaling function of the IL-13Rα2 receptor in the development of gastrointestinal fibrosis and cancer surveillance. Curr. Mol. Med. 9(6): 740-750

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