Clone:
REA242
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
IL12RB1, IL-12R-BETA1, IL12RB, IMD30, IL-12 receptor β1 subunit

Specifications for CD212 Antibody, anti-human, REAfinity™

Overview

Clone REA242 recognizes CD212, which is also known as interleukin 12 (IL-12) receptor β1 subunit. CD212 is a single-pass type I membrane protein and belongs to the type 2 subfamily of cytokines receptors. It forms a heterodimeric complex with IL-12β2 to form IL-12 receptor and with IL-23R to form IL-23 receptor. IL-12 and IL-23 are heterodimeric cytokines produced mainly by antigen-presenting cells (APCs), such as macrophages, dendritic cells, B cells, and activated T and NK cells.
Additional information: Clone REA242 displays negligible binding to Fc receptors.

Alternative names

IL12RB1, IL-12R-BETA1, IL12RB, IMD30, IL-12 receptor β1 subunit

Detailed product information

Technical specifications

CloneREA242
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate
Cross-reactivity
cynomolgus monkey (
Macaca fascicularis
)
,
rhesus monkey (
Macaca mulatta
)
AntigenCD212
Alternative names of antigenIL12RB1, IL-12R-BETA1, IL12RB, IMD30, IL-12 receptor β1 subunit
Molecular mass of antigen [kDa]70
Distribution of antigenB cells, macrophages, NK cells, T cells
Entrez Gene ID3594
RRIDAB_2656317, AB_2656318, AB_2656319, AB_2656320, AB_2656321, AB_2656322

Resources for CD212 Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD212 Antibody, anti-human, REAfinity™

Publications

  1. Chang, J. T. et al. (2000) Role of costimulation in the induction of the IL-12/IL-12 receptor pathway and the development of autoimmunity. J. Immunol. 164: 100-106
  2. Nagayama, H. et al. (2000) IL-12 responsiveness and expression of IL-12 receptor in human peripheral blood monocyte-derived dendritic cells. J. Immunol. 165: 59-66
  3. Presky, D. H. et al. (1998) Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex. J. Immunol. 160: 2174-2179

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