Clone REAL423 is an antibody fragment derived from the full CD155 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL423 recognizes the mouse CD155 antigen, which is a 70 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily. CD155, also known as poliovirus receptor (PVR), belongs to a large family of Ig molecules called nectins and nectin-like proteins, which mediate cell-cell adhesion, cell migration, and serve as entry receptors for viruses. CD155 and its family member CD112 (nectin-2) are the ligands for the activating cell-surface receptor DNAM-1 on CD8
+ T cells and natural killer (NK) cells. Mouse CD155 is found on a wide variety of cells of hematopoietic origin, on CD4
+ CD8
+ thymocytes, regulatory T cells (Tregs), other activated T cells, NKT cells, and at cell junctions on the primary vascular endothelial cells.
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.
