Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
Thrombomodulin, Fetomodulin, TM, BDCA-3

Specifications for CD141 (BDCA-3) Antibody, anti-mouse, REAfinity™


Clone REA964 recognizes the mouse CD141 antigen, which is also known as BDCA-3, thrombomodulin, or fetomodulin. CD141 is a type I cell surface glycoprotein expressed mainly on endothelial cells. CD141 functions as a specific endothelial cell receptor for thrombin. This complex cleaves protein C and the thrombin activatable fibrinolysis Inhibitor (TAFI), initiating an anticoagulant pathway.
Additional information: Clone REA964 displays negligible binding to Fc receptors.

Alternative names

Thrombomodulin, Fetomodulin, TM, BDCA-3

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
AntigenCD141 (BDCA-3)
Alternative names of antigenThrombomodulin, Fetomodulin, TM, BDCA-3
Molecular mass of antigen [kDa]60
Distribution of antigenendothelial cells, macrophages, monocytes
Entrez Gene ID21824
RRIDAB_2727343, AB_2727309, AB_2727344, AB_2727310, AB_2727347, AB_2727345, AB_2727311, AB_2727346, AB_2727342, AB_2727308

Resources for CD141 (BDCA-3) Antibody, anti-mouse, REAfinity™


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References for CD141 (BDCA-3) Antibody, anti-mouse, REAfinity™


  1. Dittman, W. A. et al. (1988) The structure and function of mouse thrombomodulin. Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells. J. Biol. Chem. 263(30): 15815-15822
  2. Bajzar, L. et al. (1996) TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex. J. Biol. Chem. 271(28): 16603-16608
  3. Isermann, B. et al. (2001) Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis. J. Clin. Invest. 108(4): 537-546

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