Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
EWI-101, Gm1016, Gm734, IGSF2

Specifications for CD101 Antibody, anti-mouse, REAfinity™


Clone REA301 recognizes the mouse CD101 antigen, a type I transmembrane glycoprotein also known as immunoglobulin superfamily member 2 (IgSF2) or V7. CD101 is expressed on monocytes, granulocytes, dendritic cells (DCs), and activated T cells. In humans CD101 inhibits the proliferative response of T cells to allogeneic cells or immobilized anti-CD3 antibody, suggesting that engagement of CD101 can antagonize TCR/CD3-mediated lymphocyte activation. Moreover, human peripheral CD8
T cells that express CD101 and CD103 display suppressive function after activation with intraepithelial cells or placental trophoblasts. In addition to its role on T cells, triggering CD101 on human cutaneous DCs inhibits T cell proliferation via interleukin 10 (IL-10) production, suggesting that the CD101 molecule may be involved in tolerance induction. Studies in mice showed that cell surface expression of CD101 is highly correlated with functional suppressor activity within CD4
T regulatory cells both
in vitro
in vivo
Additional information: Clone REA301 displays negligible binding to Fc receptors.

Alternative names

EWI-101, Gm1016, Gm734, IGSF2

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Alternative names of antigenEWI-101, Gm1016, Gm734, IGSF2
Molecular mass of antigen [kDa]112
Distribution of antigengranulocytes, monocytes, dendritic cells, T cells
Entrez Gene ID630146
RRIDAB_2904656, AB_2654345, AB_2654346, AB_2654347, AB_2654348, AB_2752032

Resources for CD101 Antibody, anti-mouse, REAfinity™


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References for CD101 Antibody, anti-mouse, REAfinity™


  1. Fernandez, I. et al. (2007)
    CD101 surface expression discriminates potency among murine FoxP3
    regulatory T cells.
    J. Immunol. 179(5): 2808-2814
  2. Mohammed, J. P. et al. (2011)
    Identification of CD101 as a susceptibility gene for
    Novosphingobium aromaticivorans
    -induced liver autoimmunity.
    J. Immunol. 187(1): 337-349
  3. Penha-Gonçalves, C. et al. (2003) Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice. Diabetes 52(6): 1551-1556

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