Clone:
REA485
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
GDCF-2, MCAF, MCP-1, Scya2, Sigje, HC11, SMC-CF, Je

Specifications for CCL2 (MCP-1) Antibody, anti-human/mouse/rat, REAfinity™

Overview

Clone REA483 recognizes the human, mouse, and rat C-C motif chemokine 2 (CCL2) antigen, which is also known as monocyte chemotactic protein 1 (MCP-1) or platelet-derived growth factor-inducible protein JE. CCL2 is a member of the C-C chemokine family, and a potent chemotactic factor for monocytes. Human CCL2 is composed of 76 amino acids and is 13 kDa in size. CCL2 is produced either constitutively or after induction by oxidative stress, cytokines, or growth factors. It is produced by many cell types, including endothelial, fibroblasts, epithelial, smooth muscle, mesangial, astrocytic, monocytic, and microglial cells. These cells are important for antiviral immune responses in the peripheral circulation and in tissues. However, monocyte/macrophages are found to be the major source of CCL2. It regulates the migration and infiltration of monocytes, memory T lymphocytes, and natural killer (NK) cells. CCL2 has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis, or atherosclerosis.
Additional information: Clone REA483 displays negligible binding to Fc receptors.

Alternative names

GDCF-2, MCAF, MCP-1, Scya2, Sigje, HC11, SMC-CF, Je

Detailed product information

Technical specifications

CloneREA485
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat, non-human primate
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
AntigenCCL2 (MCP-1)
Alternative names of antigenGDCF-2, MCAF, MCP-1, Scya2, Sigje, HC11, SMC-CF, Je
Molecular mass of antigen [kDa]9, 14(separately shown for human and mouse/rat)
Distribution of antigenendothelial cells, epithelial cells, macrophages, monocytes, astrocytes, microglia, fibroblasts, smooth muscle
Entrez Gene ID6347, 20296, 24770
RRIDAB_2651368, AB_2651369, AB_2651370, AB_2651367

Resources for CCL2 (MCP-1) Antibody, anti-human/mouse/rat, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CCL2 (MCP-1) Antibody, anti-human/mouse/rat, REAfinity™

Publications

  1. Yoshimura, T. and Leonard, E. J. (1991) Human monocyte chemoattractant protein-1 (MCP-1). Adv. Exp. Med. Biol. 305: 47-56
  2. Deshmane, S. L. et al. (2009) Monocyte chemoattractant protein-1 (MCP-1): an overview. J. Interferon Cytokine Res. 29(6): 313-326
  3. Kawahara, R. S. et al. (1989) Platelet-derived growth factor-inducible gene JE is a member of a family of small inducible genes related to platelet factor 4. J. Biol. Chem. 264(2): 679-682

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