Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Alternative names:
Caveolin 1, CAV1, CAV

Specifications for Caveolin-1 Antibody, anti-human, REAdye_lease™


Clone REAL686 is an antibody fragment derived from the full Caveolin-1 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL686 recognizes the Caveolin-1 protein, a main component of the caveolae plasma membranes found in most cell types. It links integrin subunits to the tyrosine kinase FYN and promots cell cycle progression. The coding CAV1 is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. Caveolin 1 has been shown to interact with a range of molecules via caveolin-binding motifs (CBM) through a caveolin-scaffolding domain (CSD) within caveolin-1 molecule. High Caveolin-1 levels were correlated with tumor progression, invasion and metastasis.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Caveolin 1, CAV1, CAV

Detailed product information

Technical specifications

Isotype controlControl Antibody
Hosthuman cell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Alternative names of antigenCaveolin 1, CAV1, CAV
Distribution of antigentumor cells

Resources for Caveolin-1 Antibody, anti-human, REAdye_lease™


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References for Caveolin-1 Antibody, anti-human, REAdye_lease™


  1. Razani, B. et al. (2001) Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor". J. Biol. Chem. 276(9): 6727-6738
  2. Ketteler, J. et al. (2018) Caveolin-1, cancer and therapy resistance. Int. J. Cancer 143(9): 2092-2104
  3. Volonte, D. et al. (2020) Caveolin-1, a master regulator of cellular senescence. Cancer Metastasis Rev. 39(2): 397-414

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