Clone:
REAL657
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
CDM, CALD1, CAD

Specifications for Caldesmon Antibody, anti-human, REAdye_lease™

Overview

Clone REAL657 is an antibody fragment derived from the full Caldesmon antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL657 recognizes the human protein Caldesmon, which is a calmodulin binding protein that is involved in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells by inhibiting the ATPase activity of myosin in smooth muscle. It is also implicated in cellular mitosis and receptor capping and plays a role in Schwann cell migration during peripheral nerve regeneration.
Clone REAL657 recognizes the high molecular mass variant of caldesmon (h-caldesmon) and does not react with the non-muscle variant.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

CDM, CALD1, CAD

Detailed product information

Technical specifications

CloneREAL657
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCaldesmon
Alternative names of antigenCDM, CALD1, CAD
Distribution of antigensmooth muscle

Resources for Caldesmon Antibody, anti-human, REAdye_lease™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for Caldesmon Antibody, anti-human, REAdye_lease™

Publications

  1. Horiuchi, K. Y. (1988) Interaction between caldesmon and tropomyosin in the presence and absence of smooth muscle actin. Biochemistry 27(22): 8388-8393
  2. Huber, P.A. (1997) Caldesmon. Int. J. Biochem. Cell Biol. 29(8-9): 1047-1051
  3. Gusev, N. B. (2001) Some properties of caldesmon and calponin and the participation of these proteins in regulation of smooth muscle contraction and cytoskeleton formation. Biochemistry 66(10): 1112-1121

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