Clone:
REA367
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA

Specifications for Btk Antibody, anti-human, REAfinity™

Overview

Clone REA367 recognizes the human bruton tyrosine kinase (Btk) antigen, a non-receptor tyrosine kinase belonging to the Tec family of kinases. Btk is critical for B cell–development, –differentiation, and –signaling. Moreover, Btk expression is assumed to be a prerequisite for B cell–proliferation and –survival. Consequently, Btk-deficient B lymphocytes fail to reach the mature state and are presumably doomed to premature death. Btk is reported to be associated with human disease. Thus, individuals harboring loss-of-function mutations in the gene encoding Btk virtually lack circulating B lymphocytes, are unable to generate immunoglobulins of all classes, and therefore cannot mount humoral immune responses. This primary immunodeficiency is named X-linked agammaglobulinemia.
Additional information: Clone REA367 displays negligible binding to Fc receptors.

Alternative names

AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA

Detailed product information

Technical specifications

CloneREA367
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenBtk
Alternative names of antigenAGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA
Molecular mass of antigen [kDa]76
Distribution of antigenB cells
Entrez Gene ID695
RRIDAB_2727590, AB_2651296, AB_2651297, AB_2727649

Resources for Btk Antibody, anti-human, REAfinity™

Certificates

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References for Btk Antibody, anti-human, REAfinity™

Publications

  1. Vetrie, D. et al. (1993) The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. Nature 361(6409): 226-233
  2. Tsukada, S. et al. (1993) Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell 72(2): 279-290
  3. Mohamed, A. J. et al. (2009) Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. Immunol. Rev. 228(1): 58-73

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