Clone:
REA608
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Hepatic lectin, Asialoglycoprotein receptor 1, ASGP-R 1, C-type lectin domain family 4 member H1, Hepatic lectin H1, HL-1, ASGR1, CLEC4H1

Specifications for ASGPR1 Antibody, anti-human, REAfinity™

Overview

Clone REA608 recognizes the human and rat asialoglycoprotein receptor 1 (ASGPR1) antigen, a single-pass type II membrane protein, also known as C-type lectin domain family 4 member H1 (CLEC4H1) or hepatic lectin H1 (HL-1). ASGPR1 is the major subunit of the asialoglycoprotein receptor (ASGPR) and is specifically expressed on the sinusoidal and basolateral hepatocellular membranes, but not on the bile canalicular membrane. It plays a role in the clearance of desialylated proteins from the serum through endocytosis and lysosomal degradation.
Additional information: Clone REA608 displays negligible binding to Fc receptors.

Alternative names

Hepatic lectin, Asialoglycoprotein receptor 1, ASGP-R 1, C-type lectin domain family 4 member H1, Hepatic lectin H1, HL-1, ASGR1, CLEC4H1

Detailed product information

Technical specifications

CloneREA608
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, rat
Cross-reactivityrat
AntigenASGPR1
Alternative names of antigenHepatic lectin, Asialoglycoprotein receptor 1, ASGP-R 1, C-type lectin domain family 4 member H1, Hepatic lectin H1, HL-1, ASGR1, CLEC4H1
Molecular mass of antigen [kDa]33
Distribution of antigenliver
Entrez Gene ID432
RRIDAB_2819434, AB_2857537, AB_2857533, AB_2651236, AB_2651237, AB_2651242, AB_2651243, AB_2819439

Resources for ASGPR1 Antibody, anti-human, REAfinity™

Certificates

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References for ASGPR1 Antibody, anti-human, REAfinity™

Publications

  1. Shi, B. et al. (2013) Expression of asialoglycoprotein receptor 1 in human hepatocellular carcinoma. J. Histochem. Cytochem. 61(12): 901-909
  2. Rigopoulou, E. I. et al. (2012) Asialoglycoprotein receptor (ASGPR) as target autoantigen in liver autoimmunity: lost and found. Autoimmun Rev 12(2): 260-269
  3. Yang, J. et al. (2006) Antisense oligonucleotides targeted against asialoglycoprotein receptor 1 block human hepatitis B virus replication. J. Viral Hepat. 13(3): 158-165

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