CD96 (TACTILE) antibodies, human

CD96 (TACTILE) antibodies, human

Clone: REA195 | Dilution: 1:11
Clone REA195 recognizes CD96, which is also known as T cell–activated increased late expression (TACTILE). CD96 is a single-pass transmembrane glycoprotein belonging to the Ig superfamily and consists of three extracellular Ig-like domains and a membrane proximal region rich in proline/serine/threonine. Expression of CD96 is found on T cells, NK cells, and on majority of CD34
+
CD38
-
acute myeloid leukemic (AML) cells. CD96 interacts with CD155, which is also known as polio virus receptor and promotes NK cell adhesion to target cells expressing CD155. CD96 is further described as a tumor marker for T cell–acute lymphoblastic leukemia (T-ALL) and AML.
Additional information: Clone REA195 displays negligible binding to Fc receptors.

Alternative names

TACTILE

Technical specifications

  • Antigen: CD96 (TACTILE)
  • Clone: REA195
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TACTILE
  • Distribution of antigen: T cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, Biotin
  • Selected references

    1. Fuchs, A. et al. (2004) Cutting Edge: CD96 (Tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). J. Immunol. 172: 3994-3998
    2. Meyer, D. et al. (2009) CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains. J. Biol. Chem. 284: 2235-2244
Product options: 4
for 30
tests
(1)
AUD 124.00
for 100
tests
(1)
AUD 336.00
for 30
tests
(1)
AUD 95.00
for 100
tests
(1)
AUD 278.00

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